Table 4.

Results for SVMs trained excluding one feature

Excluded feature	Precision	Recall	F1 score	MCC
Side-chain van der Waals	0.49 ± 0.04	0.62 ± 0.03	0.54 ± 0.02	0.39 ± 0.02
Side-chain hydrogen bond	0.50 ± 0.04	0.58 ± 0.05	0.54 ± 0.02	0.39 ± 0.03
Side-chain desolvation	0.49 ± 0.03	0.63 ± 0.04	0.55 ± 0.02	0.40 ± 0.03
Environment desolvation	0.50 ± 0.05	0.59 ± 0.05	0.54 ± 0.04	0.39 ± 0.04

Here, only features that if omitted lead to a decrease in performance are reported (see Additional file 2: Supplemental Table S3 for all features).