Table 3.
Increase in AZT-induced % Inhibition of HIV-1 replication by the addition of non-toxic doses of WR1065a
| Expt. Number | % HIV-1 Inhibition WR1065 alone (Concentration) | % HIV-1 Inhibition AZT alone (Concentration) | % HIV-1 Inhibition AZT + WR1065 | Increase in % inhibition HIV-1 with added WR1065 a |
| 1 | 65.2% (26.0 μM) |
71.8% (1.9 ηM) |
86.6% | 14.8% |
| 2 | 20.0% (26.0 μM) |
38.8% (1.9 ηM) |
61.4% | 29.9% |
| 3 | 67.4% (18.5 μM) |
31.5% (2.2 ηM) |
81.9% | 50.4% |
a In each experiment two identical AZT standard curves for inhibition of virus replication were compared; one curve had 1.9-23.0 ηM AZT alone and the second curve had 1.9-23.0 ηM AZT plus a constant non-toxic amount (see table) of WR1065 added to each AZT concentration. The only informative concentrations of AZT were the 1.9 and 2.2 ηM doses that alone gave % Inhibition values well below 80%. A representative set of curves (experiment 3) including all points is shown in Figure 2.