Figure 4.
Two-path impedance spectroscopy. Tricellular overexpression of TRIC-a in TRa-4 cells did not change epithelial resistance (Re) in comparison to controls, whereas bicellular overexpression of TRIC-a in TRa-8 cells induced a threefold increase of Re (** p < 0.01; n = 6, 7, and 6, respectively). This increase was caused by 14-fold rise of paracellular resistance (Rpara, ** p < 0.01), which is determined by the ion permeability of the TJ. Transcellular resistance (Rtrans) was not significantly changed.