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Hypothetical model of α-synuclein mechanisms of action on the actin cytoskeleton. According to the proposed model, both α-synucleins exert an actin bundling activity. However, only wt α-synuclein sequesters actin monomers. In contrast, A30P α-synuclein induces the formation of actin-rich foci around an A30P α-synuclein core. Blue arches, wt α-synuclein; green arches, A30P α-synuclein.
