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Structural features of haspin. (A) Overall structure of haspin showing the location of haspin-specific inserts, as well as the main secondary structure elements. The ulH helix is highlighted in green, the activation segment is in yellow, and the hairpin insert is in brown. (B) Detailed view of helix αC (magenta) embedded by hydrophobic residues shown in stick representation. (C) The ulH insert. Conserved aromatic residues that interact with the upper lobe are shown and labeled.
