Table 5.

Association of four-SNP haplotypes of PDYN with combined cases

A) Caucasians
Haplotype	Controls n (f)	Combined cases, n (f)	Haploview (PLINK) Point-wise, P	FDR q-value	OR (95% CI)
ATTC*	87.7 (0.61)	40.7 (0.50)	0.0095 (0.0125)	0.0415**	0.48 (0.27–0.84)
GCCT	25.7 (0.24)	25.7 (0.32)	0.0562 (0.0497)	0.0634	1.85 (0.98–3.50)
GTTC	15.3 (0.12)	9.3 (0.12)	0.9311 (0.9661)	0.3771	0.96 (0.40–2.28)
ACCT	1.3 (0.03)	5.3 (0.06)	0.0253 (0.0241)	0.0479**	6.84 (0.98–47.56)
B) African Americans
GTTC	61.9 (0.41)	87.7 (0.35)	0.2177 (0.1993)	0.1492	0.77 (0.51–1.17)
GCCT	54.5 (0.36)	87.1 (0.34)	0.7058 (0.6717)	0.3289	0.92 (0.61–1.40)
ATTC	20.1 (0.13)	41.3 (0.16)	0.4240 (0.4388)	0.2555	1.26 (0.71–2.24)
ACCT	11.5 (0.08)	30.9 (0.12)	0.1489 (0.1544)	0.1107	1.67 (0.83–3.41)
GTCT	2.6 (0.02)	7.2 (0.03)	0.4719 (0.4776)	0.2749	1.66 (0.40–6.97)

^*- the SNP order in haplotypes are rs1997794, rs910080, rs910079, and rs2235749

^**- FDR, p<0.05 experiment wise

n – number of subjects

f - frequency