Table 3.
Common CYP2C8 haplotypes in Caucasians‡.
| SNPs | Hap A | Hap B | Hap C1 | Hap C2 | Hap C3 | Hap D | Hap E |
|---|---|---|---|---|---|---|---|
| rs11188172 G>A (-2048, promoter) | G | A | G | G | G | G | G |
| rs17110453 T>G (-370, promoter, CYP2C8*1C) | T | T | G | G | T | T | T |
| rs7909236 C>A (-271, promoter, CYP2C8*1B) | C | A | C | C | C | C | C |
| rs1934956 G>A (intron 1) | G | G | G | G | G | G | A |
| rs3216029 or rs11572078 (intron 2) | – | – | T | T | T | – | – |
| rs2275622 G>A (intron 2) | G | A | G | G | G | G | A |
| rs11572080 G>A (exon 3, Arg139Lys, CYP2C8*3) | G | G | G | G | G | A | G |
| rs2185571 G>A (intron 3) | A | G | G | G | G | G | G |
| rs1113129 C>G (intron 5) | C | C | G | G | G | C | C |
| rs1058930 C>G (exon 5, Ile264Met, CYP2C8*4) | C | C | C | G | C | C | C |
| rs2275620 A>T (intron 7) | A | T | A | A | A | A | T |
| rs10509681 A>G (exon 8, Lys399Arg, CYP2C8*3) | A | A | A | A | A | G | A |
‡
As reported by [13].
SNPs included in the haplotypes were HapMap tagging SNPs and CYP2C8 SNPs with putative functional significance.
The haplotypes were inferred using the CYP2C8 reference sequence (AL359672). Haplotype frequencies were 30.5% (Hap A), 19.6% (Hap B), 7.4% (Hap C1), 6.5% (Hap C2), 5.4% (Hap C3), 15.3% (Hap D) and 6.9% (Hap E).
This table was adapted from [13].