Table 2.
The association of univariate baseline demographics, cardiovascular risk factors, and RA risk factors with ischemic stroke in RA (n = 1,230)*
| Value | OR (95% CI) | P | |
|---|---|---|---|
| Non-RA variables | |||
| Low-dose aspirin | 25.8 | 3.60 (2.09–6.22) | < 0.001 |
| Myocardial infarction | 6.9 | 2.58 (1.22–5.47) | 0.013 |
| Hypertension | 41.8 | 1.98 (1.16–3.37) | 0.012 |
| First comorbidity index (range 0–9), mean ± SD† | 1.6 ± 1.4 | 1.69 (1.44–1.99) | < 0.001 |
| Index comorbidity index (range 0–9), mean ± SD† | 1.7 ± 1.5 | 1.42 (1.20–1.64) | < 0.001 |
| College graduate | 24.1 | 1.42 (0.80–2.55) | 0.235 |
| Moderate or greater aerobic exercise | 9.6 | 1.29 (0.57–2.91) | 0.535 |
| Diabetes | 10.1 | 1.22 (0.54–2.76) | 0.636 |
| Any aerobic exercise | 21.8 | 1.12 (0.62–2.01) | 0.706 |
| BMI, mean ± SD kg/m2 | 26.9 ± 5.5 | 1.00 (0.95–1.05) | 0.825 |
| Ever smoked | 56.9 | 1.00 (0.58–1.72) | 0.888 |
| Current smoker | 10.8 | 0.96 (0.40–2.32) | 0.930 |
| Non-Hispanic white | 94.0 | 0.86 (0.30–2.45) | 0.777 |
| RA variables | |||
| Lifetime TJR | 17.5 | 2.13 (1.14–3.95) | 0.017 |
| Index HAQ score, mean ± SD (range 0–3) | 1.08 ± 0.73 | 2.04 (1.40–2.97) | < 0.001 |
| HAQ score, mean ± SD (range 0–3) | 1.04 ± 0.70 | 1.43 (0.98–2.11) | 0.067 |
| Disease duration, mean ± SD years | 15.9 ± 13.5 | 1.02 (1.00–1.03) | 0.100 |
*
Values are the percentage unless otherwise indicated. Variables represent baseline values except as described. RA = rheumatoid arthritis; OR = odds ratio; 95% CI = 95% confidence interval; BMI = body mass index; TJR = total joint replacement; HAQ = Health Assessment Questionnaire.
†
Conditions in the comorbidity index include pulmonary disorders, myocardial infarction, other cardiovascular disorders, stroke, hypertension, diabetes, spine/hip/leg fracture, depression, gastrointestinal ulcer, other gastrointestinal disorders, and cancer.