Table 2.

Examples for Peptide-Mediated Delivery of siRNA

CPP/Delivery System	Mode of Linkage*	Target	Cell Line	Ref.
Tat47-57, Tat-derived oligocarbamate)	c	EGFP, CDK9	HeLa	[88]
penetratin, transportan	c	luciferase, GFP	Cos-7, C166, EOMA, CHO-AA8	[89]
penetratin	c	Cu-ZN SOD-1, Caspase-3/-8/-9	primary rat hippocampal or sympathetic neurons	[90]
Tat48–60, penetratin	c	p38 MAP kinase	L929 (mouse fibroblasts), mouse lung (intratracheal)	[91]
MPG, MPGΔNLS	n-c	luciferase, GAPDH	HeLa, Cos-7, HS-68	[94]
H3K8b, H3K8b(+RGD)	n-c	β-Gal, luciferase	SVR-bag4, MDA-MB-435, C6	[21]
RVG-9R	n-c	GFP, Cu-ZN SOD-1, JEV	HeLa, Neuro2a, mouse brain (intravenously)	[95]
POD	n-c	EGFP	HER 911	[96]
Chol-R9	n-c	VEGF	CT-26, mouse (intratumoral)	[97]
EB1, MPGΔNLS,bPrPp	n-c	luciferase	HeLa, HepG2	[101]
TatU1A	n-c	EGFP, EGFR	CHO, A431,	[104]
MPGα	n-c	luciferase	HeLa, ECV 304	[55]
rCPP	n-c	EGFP, EF1A	HeLa, H1299	[29]
stearyl-R8	n-c	EGFP, MAP2B	primary rat hippocampal neurons	[206]
R8-MEND (siRNA/stearyl-R8 core)	n-c	luciferase	HeLa	[207]

^*c = covalent / n-c = non-covalent.