Table 1.

Expression and inflammation-induced alteration of the sst₄ receptor mRNA in the human lung

		Expression of the sst4 receptor mRNA normalized to the 18S ribosomal mRNA
Patient	Type of inflammation: histopathological description	Intact site	Inflamed site	Fold change of relative sst4 mRNA expression compared to the respective intact site
1	Chronic inflammation with a great number of activated macrophages accumulated in the alveolar spaces (desquamating interstitial pneumonitis), lymphocyte infiltration, peribronchial fibrosis, and black granular depositions; respiratory bronchiolitis	1.21	36.39	30.07
2	Acute inflammatory reaction on the basis of bronchiectasis with predominant granulocyte, mostly neutrophil, accumulation	1.52	1.86	1.22
3	Acute pneumonia with interstitial edema and marked neutrophil accumulation	0.60	0.78	1.3
4	Chronic inflammatory reaction, respiratory bronchiolitis, macrophage and lymphocyte infiltration without inflammatory signs in the lung parenchyma, centroacinar emphysema	1.88	9.62	5.11
5	Chronic inflammation with predominant lymphocyte infiltration, respiratory bronchiolitis with activated macrophages, smoking-induced pigment granule depositions	1.21	4.09	3.38
6	Chronic inflammation with groups of pigmented intraalveolar macrophages, destruction of the respiratory bronchioles, infiltration of lymphocytes, atelectasia	0.42	8.24	19.62
7	Chronic follicular bronchiolitis with interstitial lymphocyte infiltration, macrophage accumulation, abscess formation	0.61	7.35	12.05
8	Chronic obliterating bronchiolitis with lymphocytic predominance, anthracosis	0.69	1.92	2.78
9	Subacute inflammatory reaction on the basis of bronchiectasis with predominant granulocyte, mostly neutrophil, accumulation	1.79	2.70	1.51
10	Chronic inflammatory reaction with marked intraalveolar macrophage accumulation, excessive mucus secretion	1.91	9.07	4.75
11	Chronic inflammation with classical granulomatosus tuberculoid reaction with Langerhans-type giant cells, central necrosis, and epitheloid cells	0.54	11.01	20.39

Sst₄, somatostatin receptor subtype 4. Data show sst₄ receptor mRNA expression normalized to the 18S ribosomal mRNA as a housekeeping gene in non-inflamed and inflamed lung specimens of 11 patients. The fold changes in the inflamed areas compared to the respective intact sites as well as the histopathological diagnosis are also described.