Table 1.
Expression of the sst4 receptor mRNA normalized to the 18S ribosomal mRNA |
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Patient | Type of inflammation: histopathological description | Intact site | Inflamed site | Fold change of relative sst4 mRNA expression compared to the respective intact site |
1 | Chronic inflammation with a great number of activated macrophages accumulated in the alveolar spaces (desquamating interstitial pneumonitis), lymphocyte infiltration, peribronchial fibrosis, and black granular depositions; respiratory bronchiolitis | 1.21 | 36.39 | 30.07 |
2 | Acute inflammatory reaction on the basis of bronchiectasis with predominant granulocyte, mostly neutrophil, accumulation | 1.52 | 1.86 | 1.22 |
3 | Acute pneumonia with interstitial edema and marked neutrophil accumulation | 0.60 | 0.78 | 1.3 |
4 | Chronic inflammatory reaction, respiratory bronchiolitis, macrophage and lymphocyte infiltration without inflammatory signs in the lung parenchyma, centroacinar emphysema | 1.88 | 9.62 | 5.11 |
5 | Chronic inflammation with predominant lymphocyte infiltration, respiratory bronchiolitis with activated macrophages, smoking-induced pigment granule depositions | 1.21 | 4.09 | 3.38 |
6 | Chronic inflammation with groups of pigmented intraalveolar macrophages, destruction of the respiratory bronchioles, infiltration of lymphocytes, atelectasia | 0.42 | 8.24 | 19.62 |
7 | Chronic follicular bronchiolitis with interstitial lymphocyte infiltration, macrophage accumulation, abscess formation | 0.61 | 7.35 | 12.05 |
8 | Chronic obliterating bronchiolitis with lymphocytic predominance, anthracosis | 0.69 | 1.92 | 2.78 |
9 | Subacute inflammatory reaction on the basis of bronchiectasis with predominant granulocyte, mostly neutrophil, accumulation | 1.79 | 2.70 | 1.51 |
10 | Chronic inflammatory reaction with marked intraalveolar macrophage accumulation, excessive mucus secretion | 1.91 | 9.07 | 4.75 |
11 |
Chronic inflammation with classical granulomatosus tuberculoid reaction with Langerhans-type giant cells, central necrosis, and epitheloid cells |
0.54 |
11.01 |
20.39 |
Sst4, somatostatin receptor subtype 4. Data show sst4 receptor mRNA expression normalized to the 18S ribosomal mRNA as a housekeeping gene in non-inflamed and inflamed lung specimens of 11 patients. The fold changes in the inflamed areas compared to the respective intact sites as well as the histopathological diagnosis are also described.