Table 5.
Biodistribution of [18F]-ML04 3 h Post Administration to U87MG.wt EGFR Tumor-Bearing Mice
| Tissue | Percent of Injected Dose Per Gram of Organ (n=12) | Tumor: Tissue Activity Uptake Ratios (n=10) |
|---|---|---|
| Blood | 0.17 ± 0.02 | 7.07 ± 1.11 |
| Bone | 0.40 ± 0.05 | 2.42 ± 0.12 |
| Heart | 0.33 ± 0.02 | 3.07 ± 0.20 |
| Intestine | 2.19 ± 0.14 | 0.46 ± 0.03 |
| Kidneys | 3.98 ± 0.25 | 0.25 ± 0.02 |
| Liver | 1.63 ± 0.09 | 0.59 ± 0.02 |
| Lungs | 6.11 ± 0.50 | 0.16 ± 0.01 |
| Muscle | 0.17 ± 0.03 | 6.07 ± 0.70 |
| Skin | 0.59 ± 0.04 | 1.62 ± 0.05 |
| Spleen | 2.70 ± 0.19 | 0.37 ± 0.02 |
| Stomach | 0.94 ± 0.09 | 1.13 ± 0.09 |
| U87MG.wtEGFR tumor | 0.99 ± 0.05 |