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. 2009 Dec 4;5(12):e1000587. doi: 10.1371/journal.pcbi.1000587

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Deco et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, and E: Trace of the subthreshold membrane potential, measured intracellularly for light (A) and deep (E) anesthesia. B, F: Stationary distribution of the membrane potential for light and deep anesthesia. Red: energy function derived from the distribution. Black: maximum likelihood estimate. C, D, G, H: Distribution of up-state and down-state durations, for light (C,D) and deep (G,H) anesthesia. Dashed red: experimental data. Solid black: data from simulations.

Inline graphic — A, and E: Trace of the subthreshold membrane potential, measured intracellularly for light (A) and deep (E) anesthesia. B, F: Stationary distribution of the membrane potential for light and deep anesthesia. Red: energy function derived from the distribution. Black: maximum likelihood estimate. C, D, G, H: Distribution of up-state and down-state durations, for light (C,D) and deep (G,H) anesthesia. Dashed red: experimental data. Solid black: data from simulations.