Figure 3.

Effect of BDNF on [Ca²⁺]_i responses of ASM cells to histamine. As with ACh, histamine produced concentration-dependent increases in peak [Ca²⁺]_i responses, reflected by increases in amplitude; 1 nM BDNF significantly enhanced [Ca²⁺]_i response to high histamine concentration. In comparison, 10 nM BDNF substantially enhanced peak and amplitude responses at different histamine concentrations. Values are means (±SE). *Significant effect of 1 nM BDNF (compared with 0 nM); ^#significant effect of 10 nM BDNF (compared with 0 nM); P < 0.05.