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Effect of TNF-α on BDNF enhancement on [Ca2+]i responses to histamine. As with ACh, TNF-α alone substantially enhanced [Ca2+]i responses to histamine. Additional exposure to 10 nM BDNF further enhanced [Ca2+]i responses, greater than that with TNF-α alone. Values are means (±SE). *Significant effect of TNF-α compared with controls; #significant effect of 10 nM BDNF compared with TNF-α alone.
