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Effect of siRNA inhibition of expression of BDNF receptors (TrkB and p75NTR) on [Ca2+]i responses to ACh (top) and histamine (bottom). TrkB siRNA substantially abrogated the enhancing effect of BDNF on [Ca2+]i responses to agonist. In contrast, p75NTR siRNA had no substantial effect. *Significant siRNA (TrkB or p75NTR) effect compared with BDNF only; #significant BDNF effect compared with control (no BDNF). Values are means (±SE).
