Figure 7.
Effect of TrkB versus p75NTR siRNA on interactions between TNF-α and BDNF in [Ca2+]i responses to ACh (top) and histamine (bottom). In the absence of BDNF, neither siRNA had substantial effects on TNF-α–induced enhancement of [Ca2+]i responses to ACh or histamine. However, TrkB siRNA substantially blunted the enhancing effect of BDNF, and p75NTR siRNA had no substantial effect on TNF-α-BDNF interactions. *Significant siRNA (TrkB or p75NTR) effect compared with BDNF only; #significant BDNF effect compared with control (no BDNF). Values are means (±SE).