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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Biol Psychiatry. 2009 Mar 17;66(3):223–230. doi: 10.1016/j.biopsych.2009.01.028

Figure 1.

Figure 1

Radiolabeled [C-11]WAY-100635 binding potential (BPF) estimates for the 5-HT1A receptor in nonmedicated depressed bipolar patients and controls in 13 regions of interest. Comparison of 5-HT1A BPF between the bipolar group and control group demonstrates higher 5-HT1A BPF in bipolar patients (p=.022). Also, there was a region x sex interaction (p=0.010) and a 3-way interaction, region x sex x diagnosis (p=0.0021). Post-hoc comparisons demonstrate higher 5-HT1A BPF in the bipolar group in every ROI (see Table 2). ACN, anterior cingulate cortex; AMY, amygdala; CIN, cingulate body; DLPFC, dorsolateral prefrontal cortex; HIP, hippocampus; INS, insula; MPFC, medial prefrontal cortex; OCC, occipital cortex; PAR, parietal cortex; PHG, parahippocampal gyrus; TEM, temporal cortex; VPFC, ventral prefrontal cortex; RN, raphe nuclei. The height of each vertical bar represents the weighed means of 5-HT1A BPF for the region, and the error bar represent the standard error of the weighted estimate.