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. Author manuscript; available in PMC: 2010 Sep 24.
Published in final edited form as: J Med Chem. 2009 Sep 24;52(18):5626–5634. doi: 10.1021/jm9006577

Table 3.

Substitution effect at the middle phenyl ring

graphic file with name nihms-140774-f0003.jpg

Compound X Rx Y Ry LcrF IC50 (μM)a
14 C H C H 3.9
30 N - C H 7.4
31 C H N - 10.8
32 C F C H 20.7
33 C H C F 6.5
34 C CH3 C H 25.3
35 C H C OCH3 13.5
a

IC50 was determined using a dose response analysis with a maximum concentration of 25 μmL. Data represent the average values from two independent experiments unless specified otherwise in the Experimental section.