. Author manuscript; available in PMC: 2010 Sep 24.

Published in final edited form as: J Med Chem. 2009 Sep 24;52(18):5626–5634. doi: 10.1021/jm9006577

Table 5.

Substitution effect of R⁶

graphic file with name nihms-140774-f0005.jpg

Compound	W	R₆	LcrF IC₅₀ (μM)
14	C	NO₂	3.9^a
42	C	H	>100^b
43	N	-	>54.8 ^a
44	C	F	>100^b
45	C	CN	8.3 ^a
46	C	Cl	>100^b
47	C	CF₃	59.7^b
48	C	COCH3	39.4^b
49	C	SO₂CH₃	87.4^b
50	C	1H-pyrazole	53.7 ^a
51	C	1H-imidazole	37.3 ^a
52	C	COOH	38.5^b

IC₅₀ was determined using a dose response analysis with a maximum concentration of 25 μg/mL

IC₅₀ determined with a maximum concentration of 50 μg/mL. Data represent the average values from two independent experiments unless specified otherwise in the Experimental section.