Table 6.
Target specificity and in vitro antibacterial activity
| Compound | IC50 (μM)a | MIC (μg/mL) | ||||
|---|---|---|---|---|---|---|
| LcrF | ExsAb | SlyAc | Y. pseudotuberculosisd | S. aureuse | E. colif | |
| 14 | 3.9 | 3.5 | >53.8 | >64 | >64 | >64 |
| 22 | 8.0 | 5.9 | >55.2 | >64 | >64 | >64 |
| 36 | 7.6 | 6.7 | >52 | >64 | >64 | >64 |
a
IC50 was determined using a dose response analysis with the maximum concentration of 25 μg/mL. Data represent the average values from two independent experiments unless specified otherwise in the Experimental section
b
MAR transcription factor in P. aeruginosa
c
MarR family transcription factor in Salmonella spp.
d
YPIIIpIB1 strain of Y. pseudotuberculosis
e
RN450 strain of S. aureus
f
ATCC25922 strain of E. coli.