Table 2B.

Medical and gynecological history of caucasian breast cancer patients and age-matched control participants.

			Affected (N=196)	Unaffected (N=203)	p-value†
BRCA1 testing
	Not tested, No. (%)		27 (14)	77 (38)	7.4E-08
		Inferred negative, No. (%)	2 (7)	9 (12)
		Unknown, No. (%)	25 (92)	68 (88)
	Of tested,
		No deleterious mutation, No. (%)	138 (82)	109 (87)
		Positive for deleterious mutation, No. (%)	25 (15)	17 (13)
		VUS, No. (%)	6 (3)	0 (0)	0.09
BRCA2 testing
	Not tested, No. (%)		29 (15)	88 (43)	7.6E-10
		Inferred negative, No. (%)	4 (14)	20 (23)
		Unknown, No. (%)	25 (86)	68 (78)
	Of tested,
		No deleterious mutation, No. (%)	148 (89)	99 (86)
		Positive for deleterious mutation, No. (%)	13 (8)	11 (10)
		VUS, No. (%)	6 (3)	5 (4)	0.82
BMI, mean ± SD (range)			25.2 ± 5.1 (15.0-46.6)	24.5 ± 4.8 (16.2-41.2)	0.17
BMI18, mean ± SD (range)			20.7 ± 2.4 (16.3-30.1)	20.7 ± 2.7 (16.1-32)	0.98
Pregnancy
	Missing/Declined to state		0 (0)	1 (1)	0.99
	No. Nulliparous (%)		37 (19)	51 (25)
	No. reporting >=3 pregnancies (%)		76 (39)	78 (39)	0.25
	Age at first live birth, mean ± SD (range)		28.0 ± 6.2 (18-46)	28 ± 5.6 (18-43)	0.98
Menstruation in last 12 months, No. reporting Yes (%)			82 (42)	127 (63)	5.3E-05
Age at menopause, mean ± SD (range)			46.7 ± 5.9 (22-58)	46.1 ± 7.2 (23-56)	0.59
Reason menstrual periods stopped (%*)
	Natural menopause		44 (38)	41 (56)
	Hysterectomy alone		17 (15)	12 (16)
	Bilateral oophorectomy alone		0 (0)	2 (3)
	RT or chemotherapy alone		1 (1)	0 (0)
	Consequence of multiple therapies		45 (39)	13 (18)
	Other		7 (6)	5 (7)	0.02
Prophylactic surgeries
	Mastectomy		21 (11)	2 (1)	7.7E-05
	Oophorectomy		12 (6)	17 (8)	0.50
Oral contraceptives
	Ever used OCPs		121 (62)	142 (70)	0.10
Hormone replacement
	Ever used HRT		48 (24)	47 (23)	0.84

^*% of those reporting no menstruation in last 12 months.

^†p-values calculated using Chi-square tests for categorical variables and two-sided t-tests for continuous variables.