Table 3A.
Association of specific SNPs with breast cancer.*
|
SNP |
Distance Between SNPS (bp) |
Gene |
Chr. |
MAF** |
Data Set 1. All participants, N=399 |
Data Set 2. Excluding Individual who are BRCA1or 2 Positive, N=333 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Additive | Dominant | Additive | Dominant | |||||||||||
| N | OR | p | OR | p | N | OR | p | OR | p | |||||
| rs2075685 | XRCC4 | 5 | 0.39 | 358 | 1.33 | 0.060 | 1.75 | 0.015 | 300 | 1.43 | 0.033 | 1.94 | 0.010 | |
| rs10474081 | 18218 | XRCC4 | 5 | 0.41 | 347 | 1.32 | 0.088 | 1.77 | 0.020 | 290 | 1.25 | 0.215 | 1.75 | 0.036 |
| rs1120476 | 31760 | XRCC4 | 5 | 0.37 | 321 | 1.46 | 0.025 | 2.04 | 0.004 | 274 | 1.41 | 0.059 | 2.09 | 0.006 |
| rs6464268 | 7016 | XRCC2 | 7 | 0.16 | 358 | 1.20 | 0.340 | 1.30 | 0.268 | 298 | 1.20 | 0.375 | 1.30 | 0.309 |
| rs1063054 | NBS1 | 8 | 0.28 | 320 | 1.47 | 0.038 | 1.51 | 0.082 | 273 | 1.45 | 0.066 | 1.53 | 0.100 | |
| rs16888927 | RAD21/hHR21 | 8 | 0.31 | 339 | 0.64 | 0.014 | 0.51 | 0.004 | 289 | 0.62 | 0.014 | 0.48 | 0.004 | |
| rs16888997 | 6948 | RAD21/hHR21 | 8 | 0.29 | 347 | 0.56 | 0.003 | 0.48 | 0.002 | 294 | 0.53 | 0.003 | 0.45 | 0.002 |
| rs16889040 | 1215 | RAD21/hHR21 | 8 | 0.29 | 356 | 0.63 | 0.019 | 0.57 | 0.013 | 298 | 0.58 | 0.010 | 0.50 | 0.006 |
| rs2619681 | RAD51/RAD51a | 15 | 0.18 | 339 | 0.71 | 0.132 | 0.62 | 0.051 | 289 | 0.74 | 0.221 | 0.66 | 0.126 | |
| rs2909430 | TP53 | 17 | 0.11 | 301 | 1.71 | 0.034 | 2.01 | 0.011 | 257 | 1.58 | 0.085 | 1.86 | 0.035 | |
| rs4986763 | BRIP1 | 17 | 0.40 | 330 | 0.64 | 0.014 | 0.56 | 0.013 | 280 | 0.57 | 0.002 | 0.46 | 0.003 | |
| rs8112515 | ZNF350 | 19 | 0.21 | 318 | 0.63 | 0.042 | 0.62 | 0.060 | 271 | 0.75 | 0.252 | 0.72 | 0.219 | |
| Table 3B. Association of specific SNPs with breast cancer, adjusting for BRCA1 and BRCA2 status. | ||||||||||||||
|
SNP |
Distance between SNPS (bp) |
Gene |
Chr. |
MAF** |
Data Set 3. Including only individuals with known BRCA1 and BRCA2 status (N=306). |
|||||||||
| Additive | Dominant | |||||||||||||
| N | OR | p | OR | p | ||||||||||
| rs2075685 | XRCC4 | 5 | 0.39 | 266 | 1.13 | 0.499 | 1.34 | 0.291 | ||||||
| rs10474081 | 18218 | XRCC4 | 5 | 0.41 | 255 | 1.16 | 0.480 | 1.26 | 0.443 | |||||
| rs1120476 | 31760 | XRCC4 | 5 | 0.37 | 241 | 1.41 | 0.087 | 1.75 | 0.053 | |||||
| rs6464268 | 7016 | XRCC2 | 7 | 0.16 | 260 | 1.66 | 0.048 | 2.23 | 0.010 | |||||
| rs1063054 | NBS1 | 8 | 0.32 | 240 | 1.37 | 0.146 | 1.37 | 0.252 | ||||||
| rs16888927 | RAD21/hHR21 | 8 | 0.31 | 247 | 0.62 | 0.027 | 0.45 | 0.005 | ||||||
| rs16888997 | 6948 | RAD21/hHR21 | 8 | 0.29 | 255 | 0.53 | 0.007 | 0.43 | 0.003 | |||||
| rs16889040 | 1215 | RAD21/hHR21 | 8 | 0.29 | 259 | 0.54 | 0.009 | 0.47 | 0.006 | |||||
| rs2619681 | RAD51/RAD51a | 15 | 0.18 | 248 | 0.68 | 0.138 | 0.56 | 0.043 | ||||||
| rs2909430 | TP53 | 17 | 0.11 | 224 | 1.42 | 0.213 | 1.71 | 0.086 | ||||||
| rs4986763 | BRIP1 | 17 | 0.40 | 240 | 0.68 | 0.046 | 0.64 | 0.101 | ||||||
| rs8112515 | ZNF350 | 19 | 0.21 | 238 | 0.62 | 0.067 | 0.61 | 0.100 | ||||||
*
Models adjusted for age, education, and Ashkenazi Jewish ancestry.
**
Minor allele frequency (MAF)calculated using the unaffected individuals
*
Models adjusted for age, education, Ashkenazi Jewish ancestry, and BRCA1 and BRCA2 status.
**
Minor allele frequency (MAF) calculated using the unaffected individuals