Figure 3. Conserved response elements in the promoters of miR-433 and miR-127 of eight mammalian species.

The response elements of the miR-433 and miR-127 genes from eight different species are illustrated. Spots indicated by different colors represent putative binding sites for different transcription factors (TF). Although the miR-433/127 gene loci was located on different chromosomes in different species, the distance between miR-433 and miR-127 is very similar, which is ∼1 kb. Representative common TF binding motifs (1°∼4°) are shown, and their positions appear to be conserved in the promoter region of miR-433 and of miR-127 among different species.