Figure 2.

Tyrosine-type GSTs are less populated and less diverse than the other major subgroup of GSTs. Sequence similarity network, containing 622 sequences that are a maximum of 40% identical and span the cytosolic GSTs. Similarity is defined by pairwise BLAST alignments better than an E value of 1 × 10⁻¹²; edges at this threshold represent alignments with a median 27% identity over 200 residues, while the rest of the edges represent better alignments. Each node is colored by the classification of the sequence in SwissProt, if available. Large nodes represent sequences that are associated with the 40 structures in Figure 1.