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. 2009 Sep 25;18(24):4843–4852. doi: 10.1093/hmg/ddp456

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© The Author 2009. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Elimination of putative caspase cleavage sites in Ataxin-3 protein has little impact on protein accumulations. Cryosections immunostained for Ataxin-3 protein with Myc (green, left panels) and for nuclei with Hoechst (blue, right panels) of retinal sections from 7d adult flies. Protein was expressed with an adult onset driver (rh1-gal4), which is a sensitive method to detect subtle differences in nuclear inclusion formation. Flies expressing either the WT protein (top) or the 6M protein (bottom) showed inclusions typical of the full-length Ataxin-3 protein, being of irregular shape when assayed with this late-onset driver, and had the same onset and size. Higher magnification insets are also included in the Myc panels. Genotypes: rh1-gal4/ UAS-Myc-Atx3Q84-Flag (WT) and rh1-gal4/ UAS-Myc-Atx3Q83-Flag (6M).