Table 3.

Summary of studies on rizatriptan and quality of life

Study	Comparison	Sample size	Outcome studied	Results
Santanello, 199722	Placebo, rizatriptan 2.5 mg, 5 mg or 10 mg	n = 247	24 h MQoLQ	Improvement in three of five domains of 24 h MQoLQ in rizatriptan 10 mg group compared to placebo: social functioning, migraine symptoms, and feelings/concerns
Teall, 199823	Placebo, rizatriptan 5 mg or 10 mg	n = 1473	24 h MQoLQ	Improvement in all five domains of 24 h MQoLQ in rizatriptan 5 mg and 10 mg group compared to placebo
Ahrens, 199924	Placebo, rizatriptan 5 mg or 10 mg	n = 634	24 h MQoLQ	Rizatriptan 10 mg superior to 5 mg dose in improving quality of life
Pascual, 200020	Placebo, rizatriptan 10 mg, or zolmitriptan 2.5 mg	n = 776	24 h MQoLQ	Rizatriptan 10 mg and zolmitriptan 2.5 mg superior to placebo in all five quality of life domains
Gerth, 200125	Rizatriptan 10 mg or standard care	n = 265	24 h MQoLQ SF-36	Rizatriptan 10 mg superior to standard care in all five domains of 24 h MQoLQ; significant improvement from baseline in mental health domain of SF-36

Abbreviations: 24 h MQoLQ, 24-hour Migraine Quality of Life Questionnaire; SF-36, Short Form Health Survey.