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Pharmacokinetics of the three PDE5 inhibitors14
| Drug | Tmax (h)a | Earliest onset of action (min) | T1/2 (h)b | Duration of effect (h) | Recommended dosing time (h) prior to intercourse |
|---|---|---|---|---|---|
| Sildenafil 100 mg | 1 | 30 | 4 | 4–6 (up to 12) | 1 |
| Tadalafil 20 mg | 2 | 20 | 17.5 | 24–36 (up to72) | 0.5–12 |
| Vardenafil 20 mg | 0.7 | 10 | 4.5 | 5–7 (up to 12) | 0.5–1 |
Tmax time needed to reach maximum plasma concentration (Cmax), which corresponds to onset of action.
T1/2 half-life, which corresponds to duration of efficacy.
