Table 7.
Cox regression likelihood ratio tests results
| Disease state | Model | −2* log (L) | Test statistic (reduced – full) | p value |
|---|---|---|---|---|
| FM | Full model | 7197.040 | ||
| Model excluding STR | 7685.098 | 488.058 | <0.0001 | |
| Model excluding SAR | 7263.800 | 66.760 | <0.0001 | |
| MDD | Full model | 12562.573 | ||
| Model excluding STR | 17330.680 | 4768.110 | <0.0001 | |
| Model excluding SAR | 12630.626 | 68.053 | <0.0001 | |
| DPNP | Full model | 2940.973 | ||
| Model excluding STR | 2952.831 | 11.858 | 0.0006 | |
| Model excluding SAR | 3037.452 | 96.479 | <0.0001 | |
| GAD | Full model | 7387.324 | ||
| Model excluding STR | 8764.248 | 1376.920 | <0.0001 | |
| Model excluding SAR | 7458.218 | 70.894 | <0.0001 |
Notes: Chi-square statistic with 1 degree of freedom. standardized therapeutic response is defined as the standardized scores of percent change in therapeutic response from baseline as measured by the primary efficacy outcome measure in each disease state. Standardized Adverse Reaction is defined as standardized scores of maximum event severity defined as highest event severity in first post-baseline visit for each patient.
Abbreviations: MDD, major depressive disorder; DPNP, diabetic peripheral neuropathic pain; FM, fibromyalgia; GAD, generalized anxiety disorder; STR, Standardized Therapeutic Response; SAR, Standardized Adverse Reaction.