Cumulative incidence of MI in 324 subjects with aortic valve sclerosis and 490 subjects with normal aortic valves. Rates were adjusted for age; height; race; hypertension; smoking; use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and statin medications; body mass index; low-density lipoprotein cholesterol; N-terminal pro-B-type natriuretic peptide; systolic and diastolic blood pressure; creatinine clearance; and echocardiographic variables (diastolic function, A-wave velocity, E/A ratio, inducible ischemia, after-exercise wall motion score, aortic valve peak velocity, and mitral annular calcium).