Table 1.
Baseline characteristics of participants with normal aortic valves and aortic valve sclerosis
| Characteristic | Normal Aortic Valve (n = 490) | Aortic Valve Sclerosis (n = 324) | p Value |
|---|---|---|---|
| Age (yrs) | 64 ± 11 | 70 ± 9 | <0.0001 |
| Men | 397 (81%) | 276 (85%) | 0.14 |
| Height (cm) | 172 ± 9 | 171 ± 9 | 0.02 |
| Physically inactive | 168 (34%) | 109 (34%) | 0.82 |
| White | 270 (55%) | 215 (66%) | 0.002 |
| Black | 103 (21%) | 30 (9%) | <0.0001 |
| Other | 116 (24%) | 79 (24%) | 0.83 |
| Hypertension | 326 (67%) | 234 (73%) | 0.08 |
| HF | 75 (15%) | 63 (20%) | 0.13 |
| Diabetes mellitus | 120 (24%) | 77 (24%) | 0.80 |
| MI | 261 (54%) | 180 (56%) | 0.57 |
| Current smoker | 116 (24%) | 48 (15%) | 0.002 |
| Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker | 236 (48%) | 176 (54%) | 0.09 |
| Statin | 298 (61%) | 227 (70%) | 0.007 |
| Aspirin | 377 (77%) | 261 (81%) | 0.22 |
| β blocker | 278 (57%) | 196 (60%) | 0.29 |
| Warfarin | 37 (8%) | 20 (6%) | 0.46 |
| Body mass index (kg/m2) | 28.5 ± 5.4 | 27.8 ± 4.5 | 0.06 |
| Total cholesterol (mg/dl) | 179 ± 43 | 174 ± 40 | 0.12 |
| Low-density lipoprotein cholesterol (mg/dl) | 106 ± 35 | 101 ± 31 | 0.04 |
| High-density lipoprotein cholesterol (mg/dl) | 45 ± 13 | 46 ± 14 | 0.17 |
| Triglycerides (mg/dl) | 144 ± 133 | 137 ± 131 | 0.51 |
| C-reactive protein (mg/dl) | 4.4 ± 8.2 | 3.9 ± 6.3 | 0.43 |
| N-terminal pro-B-type natriuretic peptide (pg/ml) | 357.5 ± 793.1 | 459.9 ± 907.3 | 0.10 |
| Systolic blood pressure (mm Hg) | 129 ± 17 | 134 ± 21 | 0.0004 |
| Diastolic blood pressure (mm Hg) | 75 ± 10 | 74 ± 11 | 0.06 |
| Pulse pressure (mm Hg) | 56 ± 14 | 61 ± 17 | <0.0001 |
| Serum creatinine (mg/dl) | 1.1 ± 0.68 | 1.1 ± 0.45 | 0.63 |
| Measured creatinine clearance (ml/min) | 86.4 ± 28.3 | 77.3 ± 27 | <0.0001 |
Data presented as mean ± SD or number (percent).