Sensitivities, specificities, and cutoffs for TCA parameters at 0.99, 0.95, and 0.90 specificity cutoffs (determined using permuted longitudinal data with 1000 permutations) for largest area superpixel clusters. Only pixels with depth change from baseline ≥ 50 μm were considered outside normal limits. Although HRT measurements are generally expressed in millimeters, the cutoff values are expressed in micrometers, to prevent rounding to zero in some cases.