Table 4.
Comparison of TCA Measurements among Progressed, Nonprogressed, and Healthy Eyes for 35 Parameters
| Required Superpixel Depth Change | Parameter | Progressed Eyes by Disc and/or GPA (n = 36) | Nonprogressed Eyes (n = 210) | Healthy Eyes (n = 21) | P | Progressed Eyes by disc (n = 20) |
|---|---|---|---|---|---|---|
| Superpixel change ≥ 0 μm | CSIZEdisc (s-pixels) | 57.9 (36.1–79.8) | 44.2 (34.9–53.4) | 9.3 (3.8–14.9) | 0.036* | 68.0 (38.1–98.0) |
| CAREAdisc (mm2) | 0.144 (0.067–0.161) | 0.096 (0.075–0.116) | 0.018 (0–0.082) | 0.047* | 0.143 (0.057–0.228) | |
| CVOLdisc (mm3) | 0.013 (0.001–0.018) | 0.001 (0.007–0.012) | 0.002 (0–0.009) | 0.071 | 0.018 (0.001–0.026) | |
| CSIZE% | 5.03 (2.90–7.17) | 4.41 (3.50–5.32) | 0.94 (0–3.81) | 0.057 | 5.96 (2.70–9.23) | |
| CSIZEtotal (s-pixels) | 157.8 (102.4–213.4) | 163.4 (139.7–187.1) | 60.3 (37.5–83.0) | 0.035† | 132.7 (68.2–197.2) | |
| CAREAtotal (mm2) | 0.327 (0.210–0.494) | 0.344 (0.294–0.394) | 0.123 (0–0.280) | 0.032† | 0.279 (0.144–0.414) | |
| CVOLtotal (mm3) | 0.028 (0.018–0.037) | 0.022 (0.018–0.026) | 0.007 (0.004–0.010) | 0.028* | 0.025 (0.009–0.042) | |
| Superpixel change ≥20 μm | CSIZEdisc (s-pixels) | 50.4 (29.0–71.8) | 38.3 (29.9–46.8) | 8.4 (3.0–13.8) | 0.036* | 64.3 (25.1–103.5) |
| CAREAdisc (mm2) | 0.104 (0.060–0.149) | 0.082 (0.063–0.101) | 0.017 (0.006–0.027) | 0.049* | 0.135 (0.053–0.217) | |
| CVOLdisc (mm3) | 0.012 (0.006–0.017) | 0.009 (0.007–0.010) | 0.002 (0.001–0.003) | 0.085 | 0.017 (0.006–0.027) | |
| CSIZE% | 4.60 (2.84–6.36) | 3.82 (2.95–4.70) | 0.84 (0.33–1.35) | 0.062 | 5.63 (2.45–8.82) | |
| CSIZEtotal (s-pixels) | 135.5 (87.5–183.6) | 129.2 (107.1–150.9) | 47.0 (28.9–65.0) | 0.054 | 109.7 (45.7–173.6) | |
| CAREAtotal (mm2) | 0.280 (0.181–0.379) | 0.272 (0.226–0.318) | 0.096 (0.059–0.134) | 0.052 | 0.230 (0.097–0.363) | |
| CVOLtotal (mm3) | 0.027 (0.016–0.037) | 0.020 (0.016–0.023) | 0.006 (0.003–0.009) | 0.024* | 0.024 (0.008–0.040) | |
| Superpixel change ≥ 50 μm | CSIZEdisc (s-pixels) | 33.8 (14.6–52.9) | 20.7 (15.1–26.3) | 2.7 (1.1–4.3) | 0.026* | 49.6 (13.8–85.5) |
| CAREAdisc (mm2) | 0.070 (0.031–0.110) | 0.044 (0.032–0.057) | 0.005 (0.002–0.008) | 0.038* | 0.104 (0.029–0.179) | |
| CVOLdisc (mm3) | 0.010 (0.005–0.016) | 0.006 (0.004–0.009) | 0.001 (0.0002–0.001) | 0.081 | 0.015 (0.006–0.025) | |
| CSIZE% | 3.05 (1.49–4.62) | 2.07 (1.49–2.64) | 0.27 (0.12–0.42) | 0.047* | 4.30 (1.39–7.22) | |
| CSIZEtotal (s-pixels) | 81.8 (41.7–121.8) | 50.7 (39.7–61.8) | 14.0 (3.3–24.7) | 0.013* | 78.0 (17.0–139.10) | |
| CAREAtotal (mm2) | 0.170 (0.09–0.254) | 0.108 (0.083–0.132) | 0.029 (0–0.107) | 0.006* | 0.164 (0.037–0.291) | |
| CVOLtotal (mm3) | 0.021 (0.011–0.031) | 0.012 (0.009–0.014) | 0.003 (0.0005–0.001) | 0.008‡ | 0.022 (0.007–0.037) | |
| Superpixel change ≥ 100 μm | CSIZEdisc (s-pixels) | 11.8 (5.4–18.2) | 6.3 (3.7–9.0) | 0.7 (0. 1.9) | 0.114 | 18.1 (1.6–34.6) |
| CAREAdisc (mm2) | 0.025 (0.006–0.043) | 0.018 (0.008–0.020) | 0.001 (0.003) | 0.136 | 0.038 (0.004–0.072) | |
| CVOLdisc (mm3) | 0.005 (0.002–0.008) | 0.003 (0.002–0.005) | 0.003 (0–0.001) | 0.297 | 0.008 (0.002–0.014) | |
| CSIZE% | 1.05 (0.34–1.77) | 0.62 (0.37–0.88) | 0.07 (0–0.17) | 0.145 | 1.54 (0.22–2.87) | |
| CSIZEtotal (s-pixels) | 20.7 (7.1–34.2) | 9.9 (6.5–13.3) | 2.9 (0–5.8) | 0.030* | 20.1 (1.64–38.56) | |
| CAREAtotal (mm2) | 0.043 (0.015–0.071) | 0.022 (0.014–0.029) | 0.006 (0–0.012) | 0.042 | 0.042 (0.004–0.081) | |
| CVOLtotal (mm3) | 0.008 (0.004–0.012) | 0.004 (0.003–0.006) | 0.001 (0–0.002) | 0.115 | 0.008 (0.002–0.014) | |
| Superpixel change ≥ 200 μm | CSIZEdisc (s-pixels) | 1.7 (0.3–3.2) | 1.6 (0.6–2.7) | 0.1 (0–0.39) | 0.630 | 2.85 (0.1–5.6) |
| CAREAdisc (mm2) | 0.003 (0.001–0.006) | 0.004 (0.001–0.006) | <0.001 (0–0.001) | 0.644 | 0.006 (0.003–0.011) | |
| CVOLdisc (mm3) | 0.002 (0.0003–0.003) | 0.001 (0.0005–0.002) | <0.0001 (0–0.003) | 0.603 | 0.002 (0.0001–0.005) | |
| CSIZE% | 0.15 (0.02–0.28) | 0.16 (0.06–0.26) | 0.01 (0–0.02) | 0.621 | 0.26 (0.02–0.49) | |
| CSIZEtotal (s-pixels) | 2.0 (0.4–3.6) | 1.8 (0.7–2.8) | 0.1 (0–0.3) | 0.571 | 2.8 (0.1–5.6) | |
| CAREAtotal (mm2) | 0.004 (0–0.009) | 0.004 (0–0.006) | 0.001 (0–0.007) | 0.593 | 0.006 (0.0003–0.011) | |
| CVOLtotal | 0.002 (0–0.004) | 0.001 (0–0.002) | <0.0001 (0–0.0001) | 0.556 | 0.002 (0.0001–0.005) |
Shown is the largest area cluster when the required total height change from baseline for each pixel was ≥0, ≥20, ≥50, ≥100, and ≥200 μm. Data are expressed as the mean (95% CI). Parameters are as defined in Table 2. ANOVA and corresponding pair-wise comparisons tests include only progressed eyes by disc and/or GPA, nonprogressed eyes, and healthy eyes. The ANOVA probability is in bold for comparisons with differences at P ≤ 0.05.
*
Significant difference (Tukey-Kramer HSD with α = 0.05) between progressed and healthy eyes.
†
Significant differences (Tukey-Kramer HSD with α = 0.05) between nonprogressed and healthy eyes.
‡
Significant difference (Tukey-Kramer HSD with α = 0.05) between progressed and healthy eyes and between progressed and nonprogressed eyes.