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. Author manuscript; available in PMC: 2009 Nov 17.
Published in final edited form as: J Immunol. 2008 Oct 1;181(7):5035–5044. doi: 10.4049/jimmunol.181.7.5035

FIGURE 4.

FIGURE 4

AnxA1-deficient mice have more severe histopathologic injury in DSS-induced colitis. Representative photomicrographs of H&E-stained histologic sections (A) demonstrate more severe colonic injury in AnxA1 (−/−) animals compared with WT controls following 7 days of DSS treatment. Note the increased degree of epithelial injury, increased leukocyte infiltration, and involvement of submucosal tissues in AnxA1 (−/−) mice (inset, arrows). Histologic scoring of colonic injury (B) is significantly higher than that of WT DSS-treated animals (*, p-value <0.05, n = 7 mice). Colonic MPO activity (C) is also significantly higher in AnxA1 (−/−) mice compared with WT BALB/c animals following DSS treatment (*, p-value <0.05, n = 7 mice).