Table 4. Baseline patient characteristics (n=337).
| Grade 0 (n=55) | Grade 1–2 (n=46) | Grade 3–4 (n=236) | |
|---|---|---|---|
| Age (years) | |||
| Median (range) | 63 (45–78) | 64 (43–81) | 65 (33–81) |
| Sex | |||
| Male (n) (%) | 43 (78) | 36 (78) | 159 (67) |
| Female (n) (%) | 12 (22) | 10 (22) | 77 (33) |
| Smoking history | |||
| Current smokers (n) (%) | 25 (45) | 24 (52) | 91 (39) |
| Former smokers (n) (%) | 17 (31) | 9 (20) | 70 (30) |
| Non-smokers (n) (%) | 11 (20) | 10 (22) | 65 (28) |
| Unknown (n) (%) | 2 (4) | 3 (7) | 10 (4) |
| NSCLC stage | |||
| IIIB (n) (%) | 15 (27) | 10 (22) | 37 (16) |
| IV (n) (%) | 40 (73) | 36 (78) | 199 (84) |
| ECOG performance status | |||
| 0 (n) (%) | 16 (29) | 16 (35) | 112 (47) |
| 1 (n) (%) | 39 (71) | 30 (65) | 124 (53) |
| Weight loss | |||
| < 5% (n) (%) | 46 (84) | 39 (85) | 198 (84) |
| >5% (n) (%) | 9 (16) | 7 (15) | 38 (16) |
| LDH | |||
| Normal (n) (%) | 40 (73) | 32 (70) | 172 (73) |
| High (n) (%) | 15 (27) | 14 (30) | 64 (27) |
| Bone metastases | |||
| No (n) (%) | 42 (76) | 36 (78) | 170 (72) |
| Yes (n) (%) | 13 (24) | 10 (22) | 66 (28) |
| Liver metastases | |||
| No (n) (%) | 52 (95) | 43 (93) | 217 (92) |
| Yes (n) (%) | 3 (5) | 3 (7) | 19 (8) |
| Skin metastases | |||
| No (n) (%) | 54 (98) | 45 (98) | 233 (99) |
| Yes (n) (%) | 1 (2) | 1 (2) | 3 (1) |
| Pretreatment neutrophil count | |||
| Mean (per mm3±s.d.) | 5828±2211 | 4968±1732 | 4427±2275 |
Abbreviations: ECOG=Eastern Cooperative Oncology Group; LDH=lactate dehydrogenase; NSCLC=non-small-cell lung cancer.