Table 5. Multivariate proportional-hazards regression analysis for associations between overall survival and worst grade of neutropenia (n=337).
| Hazards ratio | 95% CI | P-value | |
|---|---|---|---|
| Neutropenia | |||
| Grade 0 | 1 | — | — |
| Grade 1/2 | 0.59 | 0.36–0.97 | 0.036 |
| Grade 3/4 | 0.71 | 0.49–1.03 | 0.072 |
| Sex | |||
| Male | 1 | — | — |
| Female | 0.75 | 0.53–1.06 | 0.104 |
| Smoking history | |||
| Non-/former smokers | 1 | — | — |
| Current smokers | 1.67 | 1.23–2.28 | 0.001 |
| Stage | |||
| IIIB | 1 | — | — |
| IV | 1.12 | 0.77–1.64 | 0.551 |
| Performance status | |||
| 0 | 1 | — | — |
| 1 | 2.08 | 1.53–2.84 | <0.0001 |
| Weight loss | |||
| <5% | 1 | — | — |
| ⩾5% | 1.06 | 0.74–1.50 | 0.765 |
| Serum LDH | |||
| Normal | 1 | — | — |
| High | 1.64 | 1.20–2.25 | 0.002 |
| Bone metastasis | |||
| No | 1 | — | — |
| Yes | 1.23 | 0.87–1.72 | 0.240 |
| Liver metastasis | |||
| No | 1 | — | — |
| Yes | 1.62 | 1.02–2.60 | 0.043 |
| Skin metastasis | |||
| No | 1 | — | — |
| Yes | 4.25 | 1.50–12.03 | 0.006 |
| Neutrophil count | |||
| < 4500/mm3 | 1 | — | — |
| ⩾4500/mm3 | 1.56 | 1.18–2.05 | 0.002 |
| Number of treatment cycles | |||
| 1 | 1 | — | — |
| 2 | 0.94 | 0.48–1.84 | 0.866 |
| 3 | 1.07 | 0.58–1.96 | 0.838 |
| 4 | 0.88 | 0.48–1.61 | 0.674 |
| 5 | 0.59 | 0.29–1.21 | 0.151 |
| 6 | 0.58 | 0.34–1.01 | 0.054 |
Abbreviations: CI=confidence interval; LDH=lactate dehydrogenase.