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. 2009 Oct 20;101(10):1769–1781. doi: 10.1038/sj.bjc.6605369

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Copyright © 2009 Cancer Research UK

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Immunohistochemical staining of Snail in DCIS. (A) A schematic representation of a typical HIF-1α staining appearance, with increasing staining intensity and number of positive cells approaching the central necrosis. (B) Nuclear expression of Snail was gradually increased in proximity to the central necrosis of DCIS. (C) Magnification ( × 20) of the framed area in panel B. Arrows indicate cells with intense nuclear Snail staining.