Table 2. Distribution of Snail staining category according to clinicopathological and molecular parameters of invasive breast cancer.

	Snail nuclear staining
Variable	Negative (n=293)	Positive (n=91)	P a
Tumour size (mm)			0.901
⩽20	106	34
>20	186	57
Missing cases: 117
Tumour type			0.361b
Ductal	246	75
Lobular	20	7
Medullary	14	7
Missing cases: 131
Lymph node status			0.893
Negative	80	26
Positive	212	65
Missing cases: 117
NHG			0.003b
I	35	6
II	132	30
III	116	52
Missing cases: 129
Ki67 positive (%)			0.024b
0–1	41	7
2–10	84	24
11–25	67	27
26–50	35	14
51–100	31	15
Missing cases: 155
ERα positive (%)			0.002
<10	76	41
⩾10	203	50
Missing cases: 130
PR positive (%)			0.006
<10	79	40
⩾10	194	48
Missing cases: 139
HIF-1α (%)			0.129b
0–1	176	53
2–10	36	18
11–100	19	8
Missing cases: 190
CAIX			0.040
Negative	219	67
Positive	21	14
Missing cases: 179

Abbreviations: CAIX=carbonic anhydrase-IX; ER=oestrogen receptor; HIF=hypoxia-inducible factor; NHG=Nottingham Histologic Grade; PR=progesterone receptor.

^aCorrelations were calculated using Fisher's exact test (two-sided) unless otherwise specified.

^bWilcoxon/Mann–Whitney test (two-sided).