Table 2. Relative risks of pancreatic cancer (RR) for the offspring of individuals affected by cancer.
|
Parental age of diagnosis with cancer
|
||||||||
|---|---|---|---|---|---|---|---|---|
|
Any age
|
0–55
|
56–71
|
72+
|
|||||
| Parental cancer site | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) |
| Upper aerodigestive tract | 25 | 1.06 (0.71–1.56) | 5 | 1.79 (0.75–4.31) | 13 | 1.15 (0.67–1.99) | 7 | 0.74 (0.35–1.55) |
| Oesophagus | 11 | 0.98 (0.54–1.77) | 5 | 0.98 (0.41–2.35) | 5 | 0.93 (0.39–2.24) | ||
| Stomach | 82 | 1.09 (0.87–1.36) | 8 | 1.25 (0.63–2.51) | 36 | 1.09 (0.78–1.51) | 38 | 1.08 (0.78–1.48) |
| Small intestine | 3 | 0.53 (0.17–1.64) | ||||||
| Colon | 109 | 1.03 (0.85–1.25) | 13 | 1.62 (0.94–2.80) | 42 | 1.02 (0.75–1.39) | 54 | 0.97 (0.74–1.27) |
| Rectum | 73 | 1.23 (0.97–1.55) | 6 | 1.20 (0.54–2.67) | 28 | 1.13 (0.78–1.65) | 39 | 1.33 (0.97–1.82) |
| Liver | 63 | 1.41 (1.10–1.81) | 4 | 1.67 (0.63–4.45) | 13 | 0.72 (0.42–1.24) | 46 | 1.90 (1.42–2.55) |
| Pancreas | 84 | 1.93 (1.55–2.40) | 10 | 3.32 (1.78–6.18) | 41 | 2.19 (1.61–2.98) | 33 | 1.54 (1.09–2.17) |
| Larynx | 15 | 1.98 (1.19–3.28) | 8 | 1.96 (0.98–3.92) | 6 | 2.41 (1.08–5.37) | ||
| Lung | 136 | 1.50 (1.27–1.79) | 20 | 2.52 (1.62–3.92) | 56 | 1.26 (0.96–1.64) | 60 | 1.58 (1.22–2.04) |
| Breast | 156 | 1.12 (0.95–1.32) | 27 | 1.02 (0.70–1.49) | 76 | 1.25 (1.00–1.58) | 53 | 1.05 (0.80–1.37) |
| Cervix uteri | 18 | 0.68 (0.43–1.08) | 9 | 0.71 (0.37–1.37) | 8 | 0.81 (0.41–1.63) | ||
| Endometrium | 41 | 1.19 (0.87–1.62) | 10 | 1.61(0.86–2.99) | 21 | 1.27 (0.82–1.95) | 10 | 0.88 (0.47–1.64) |
| Ovary | 22 | 0.72 (0.47–1.09) | 6 | 0.94 (0.42–2.08) | 10 | 0.65 (0.35–1.21) | 6 | 0.68 (0.31–1.52) |
| Prostate | 197 | 1.02 (0.88–1.18) | 8 | 1.08 (0.54–2.17) | 65 | 0.99 (0.77–1.26) | 124 | 1.03 (0.86–1.23) |
| Testis | 2 | 1.16 (0.29–4.64) | ||||||
| Other male genital organs | 3 | 1.30 (0.42–4.02) | ||||||
| Kidney | 60 | 1.37 (1.06–1.76) | 7 | 1.36 (0.65–2.85) | 27 | 1.27 (0.87–1.86) | 26 | 1.51 (1.03–2.22) |
| Urinary organs | 66 | 1.03 (0.81–1.32) | 4 | 0.82 (0.31–2.18) | 27 | 1.02 (0.70–1.49) | 35 | 1.09 (0.78–1.52) |
| Melanoma | 34 | 1.30 (0.92–1.82) | 9 | 1.66 (0.86–3.21) | 16 | 1.54 (0.94–2.52) | 9 | 0.89 (0.46–1.70) |
| Squamous cell skin | 47 | 0.88 (0.66–1.18) | 2 | 0.77 (0.19–3.08) | 13 | 0.92 (0.53–1.59) | 32 | 0.88 (0.62–1.24) |
| Eye | 2 | 0.61 (0.15–2.43) | ||||||
| Nervous system | 33 | 1.00 (0.71–1.41) | 5 | 0.70 (0.29–1.69) | 20 | 1.21 (0.78–1.87) | 8 | 0.89 (0.45–1.79) |
| thyroid gland | 15 | 1.53 (0.92–2.54) | 4 | 1.77 (0.67–4.73) | 8 | 1.82 (0.91–3.65) | 3 | 0.98 (0.32–3.03) |
| Endocrine glands | 28 | 1.41 (0.97–2.05) | 6 | 1.87 (0.84–4.17) | 12 | 1.27 (0.72–2.23) | 10 | 1.44 (0.77–2.68) |
| Connective tissue | 10 | 1.20 (0.64–2.23) | 2 | 1.57 (0.39–6.27) | 6 | 1.80 (0.81–4.02) | 2 | 0.54 (0.14–2.17) |
| Non-Hodgkin's lymphoma | 31 | 0.86 (0.60–1.23) | 3 | 0.84 (0.27–2.61) | 12 | 0.83 (0.47–1.46) | 16 | 0.89 (0.55–1.46) |
| Hodgkin's disease | 8 | 1.33 (0.66–2.66) | 3 | 1.06 (0.34–3.29) | 4 | 2.27 (0.85–6.06) | ||
| Leukaemia | 34 | 0.88 (0.63–1.24) | 4 | 0.98 (0.37–2.61) | 11 | 0.67 (0.37–1.22) | 19 | 1.06 (0.68–1.67) |
Bold signifies P<0.05.