Table 3. Relative risk of tumours (RR) for the offspring of individuals affected by pancreatic cancer.
|
Parental age of diagnosis with pancreatic cancer
|
||||||||
|---|---|---|---|---|---|---|---|---|
|
Any
|
0–55
|
56–71
|
72+
|
|||||
| Offspring cancer site | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) |
| Upper aerodigestive tract | 60 | 1.25 (0.97–1.61) | 6 | 1.41 (0.63–3.15) | 35 | 1.63 (1.16–2.27) | 19 | 0.87 (0.55–1.36) |
| Salivary glands | 18 | 2.06 (1.29–3.29) | 9 | 2.17 (1.13–4.20) | 9 | 2.44 (1.26–4.71) | ||
| Oesophagus | 21 | 1.16 (0.75–1.79) | 2 | 1.63 (0.41–6.52) | 15 | 1.90 (1.14–3.16) | 4 | 0.45 (0.17–1.19) |
| Stomach | 47 | 1.13 (0.85–1.51) | 25 | 1.37 (0.93–2.03) | 21 | 1.05 (0.69–1.63) | ||
| Small intestine | 19 | 1.62 (1.02–2.55) | 5 | 0.95 (0.39–2.28) | 13 | 2.38 (1.38–4.13) | ||
| Colon | 182 | 1.28 (1.10–1.48) | 15 | 1.34 (0.81–2.23) | 79 | 1.27 (1.01–1.58) | 88 | 1.29 (1.04–1.60) |
| Rectum | 98 | 1.11 (0.91–1.36) | 5 | 0.79 (0.33–1.89) | 51 | 1.33 (1.01–1.75) | 42 | 0.98 (0.72–1.32) |
| Liver | 58 | 1.52 (1.17–1.98) | 5 | 1.80 (0.75–4.33) | 28 | 1.69 (1.16–2.46) | 25 | 1.34 (0.90–1.99) |
| Pancreas | 84 | 1.93 (1.55–2.40) | 10 | 3.32 (1.78–6.18) | 41 | 2.19 (1.61–2.98) | 33 | 1.54 (1.09–2.17) |
| Larynx | 15 | 1.26 (0.75–2.10) | 7 | 1.32 (0.63–2.79) | 7 | 1.22 (0.58–2.58) | ||
| Lung | 191 | 1.18 (1.02–1.36) | 19 | 1.66 (1.06–2.61) | 82 | 1.17 (0.94–1.45) | 90 | 1.13 (0.92–1.39) |
| Breast | 726 | 1.21 (1.13–1.31) | 75 | 1.32 (1.05–1.66) | 361 | 1.33 (1.20–1.48) | 290 | 1.09 (0.97–1.22) |
| Cervix uteri | 101 | 1.44 (1.18–1.76) | 13 | 1.35 (0.78–2.33) | 55 | 1.61 (1.24–2.10) | 33 | 1.28 (0.91–1.81) |
| Endometrium | 107 | 1.18 (0.97–1.42) | 5 | 0.80 (0.33–1.91) | 41 | 1.05 (0.77–1.43) | 61 | 1.33 (1.04–1.72) |
| Ovary | 104 | 1.20 (0.99–1.45) | 11 | 1.30 (0.72–2.35) | 51 | 1.30 (0.99–1.71) | 42 | 1.09 (0.80–1.48) |
| Prostate | 316 | 1.01 (0.90–1.12) | 11 | 0.67 (0.37–1.20) | 151 | 1.12 (0.96–1.32) | 154 | 0.94 (0.80–1.10) |
| Testis | 65 | 1.35 (1.06–1.73) | 8 | 1.04 (0.52–2.07) | 38 | 1.57 (1.14–2.16) | 19 | 1.22 (0.78–1.92) |
| Other male genital organs | 12 | 1.88 (1.06–3.34) | 5 | 1.70 (0.71–4.12) | 7 | 2.43 (1.15–5.13) | ||
| Kidney | 67 | 0.98 (0.77–1.25) | 31 | 1.02 (0.72–1.45) | 35 | 1.09 (0.78–1.51) | ||
| Urinary organs | 110 | 1.11 (0.92–1.34) | 8 | 1.09 (0.55–2.19) | 47 | 1.08 (0.81–1.44) | 55 | 1.15 (0.89–1.51) |
| Melanoma | 241 | 1.25 (1.10–1.42) | 32 | 1.47 (1.04–2.08) | 133 | 1.47 (1.24–1.74) | 76 | 0.96 (0.77–1.21) |
| Squamous cell skin | 65 | 1.06 (0.83–1.35) | 5 | 1.02 (0.43–2.46) | 27 | 0.99 (0.68–1.45) | 33 | 1.13 (0.81–1.60) |
| Eye | 5 | 0.78 (0.32–1.88) | 2 | 0.68 (0.17–2.71) | 3 | 1.06 (0.34–3.29) | ||
| Nervous System | 151 | 0.98 (0.84–1.15) | 21 | 1.13 (0.74–1.74) | 61 | 0.84 (0.66–1.09) | 69 | 1.10 (0.81–1.40) |
| Thyroid gland | 35 | 0.83 (0.59–1.16) | 8 | 1.49 (0.74–2.97) | 14 | 0.69 (0.41–1.17) | 13 | 0.80 (0.46–1.38) |
| Endocrine glands | 93 | 1.28 (1.04–1.57) | 15 | 1.96 (1.18–3.26) | 40 | 1.19 (0.87–1.62) | 38 | 1.22 (0.89–1.68) |
| Connective tissue | 25 | 0.99 (0.67–1.48) | 3 | 0.99 (0.32–3.06) | 9 | 0.76 (0.39–1.46) | 13 | 1.28 (0.74–2.21) |
| Non-Hodgkin's lymphoma | 115 | 1.14 (0.94–1.37) | 14 | 1.46 (0.87–2.47) | 51 | 1.11 (0.84–1.46) | 50 | 1.10 (0.83–1.45) |
| Hodgkin's disease | 34 | 1.16 (0.82–1.62) | 6 | 1.35 (0.61–3.02) | 11 | 0.77 (0.43–1.39) | 17 | 1.67 (1.04–2.69) |
| Leukaemia | 88 | 1.03 (0.84–1.27) | 10 | 1.03 (0.56–1.92) | 45 | 1.13 (0.85–1.52) | 33 | 0.90 (0.64–1.27) |
Bold signifies P<0.05.