Table 4. Relative risk of pancreatic cancer (RR) diagnosed in siblings of individuals affected by cancer.
Age of diagnosis of siblings with cancer
|
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---|---|---|---|---|---|---|
Any age
|
0–55
|
56–71
|
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Sibling cancer site | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) |
Upper aerodigestive tract | 8 | 1.28 (0.64–2.57) | 6 | 2.03 (0.91–4.53) | 2 | 0.61 (0.15–2.45) |
Oesophagus | 8 | 3.39 (1.69–6.79) | 2 | 3.16 (0.79–12.6) | 6 | 3.49 (1.57–7.77) |
Stomach | 9 | 1.35 (0.70–2.59) | 3 | 1.13 (0.36–3.50) | 6 | 1.51 (0.68–3.37) |
Colon | 18 | 0.96 (0.60–1.53) | 7 | 0.96 (0.46–2.01) | 11 | 0.96 (0.53–1.74) |
Rectum | 13 | 1.09 (0.63–1.89) | 3 | 0.69 (0.22–2.15) | 10 | 1.32 (0.71–2.46) |
Liver | 11 | 2.07 (1.15–3.75) | 10 | 2.88 (1.55–5.36) | ||
Pancreas | 19 | 3.26 (2.07–5.12) | 9 | 5.06 (2.63–9.74) | 10 | 2.47 (1.33–4.59) |
Larynx | 2 | 1.11 (0.28–4.46) | ||||
Lung | 25 | 1.09 (0.73–1.61) | 13 | 1.74 (1.01–3.00) | 12 | 0.77 (0.44–1.37) |
Breast | 88 | 1.19 (0.96–1.48) | 59 | 1.37 (1.06–1.77) | 29 | 0.95 (0.66–1.38) |
Cervix uteri | 7 | 0.79 (0.38–1.65) | 6 | 0.79 (0.35–1.75) | ||
Endometrium | 18 | 1.50 (0.95–2.39) | 8 | 1.68 (0.84–3.36) | 10 | 1.39 (0.75–2.59) |
Ovary | 11 | 0.95 (0.52–1.71) | 9 | 1.26 (0.66–2.43) | 2 | 0.45 (0.11–1.82) |
Prostate | 47 | 1.19 (0.89–1.59) | 9 | 2.36 (1.23–4.54) | 38 | 1.07 (0.77–1.47) |
Testis | 4 | 1.09 (0.41–2.90) | 3 | 0.88 (0.28–2.72) | ||
Other male genital organs | 3 | 3.57 (1.15–11.1) | 3 | 6.48 (2.09–20.1) | ||
Kidney | 11 | 1.17 (0.65–2.11) | 8 | 1.86 (0.93–3.73) | 3 | 0.59 (0.19–1.84) |
Urinary organs | 17 | 1.24 (0.77–2.00) | 9 | 1.64 (0.85–3.16) | 8 | 0.98 (0.49–1.96) |
Melanoma | 19 | 0.94 (0.60–1.48) | 13 | 0.98 (0.57–1.69) | 6 | 0.88 (0.39–1.95) |
Squamous cell skin | 10 | 1.31 (0.70–2.44) | 4 | 1.31 (0.49–3.49) | 6 | 1.31 (0.59–2.93) |
Eye | 3 | 3.26 (1.05–10.1) | 3 | 4.70 (1.52–14.6) | ||
Nervous system | 15 | 0.88 (0.53–1.45) | 10 | 0.92 (0.49–1.71) | 5 | 0.80 (0.33–1.93) |
Endocrine glands | 13 | 1.38 (0.80–2.39) | 5 | 0.81 (0.34–1.95) | 8 | 2.51 (1.25–5.02) |
Connective tissue | 9 | 3.12 (1.62–6.00) | 5 | 2.70 (1.12–6.50) | 4 | 3.87 (1.45–10.3) |
Hodgkin's disease | 3 | 1.08 (0.35–3.36) | 3 | 1.25 (0.40–3.89) | ||
Non-Hodgkin's lymphoma | 10 | 0.76 (0.41–1.41) | 6 | 0.87 (0.39–1.95) | 4 | 0.63 (0.24–1.69) |
Leukaemia | 8 | 0.88 (0.44–1.75) | 7 | 1.54 (0.73–3.24) |
Bold signifies P<0.05.