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. 2009 Oct 27;101(10):1683–1691. doi: 10.1038/sj.bjc.6605403

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Copyright © 2009 Cancer Research UK

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Reduced tumour growth and enhanced survival from VNP pRA-TR with induction by γ-irradiation. Balb/c mice received intravenous injection of 100 000 cfu g⁻¹ VNP pRA-ZsG, VNP pRA-TR, or PBS at 21 days after establishing 4T1/red tumours. (A) Tumour volumes (mm³) after experimental treatments in mice receiving no irradiation, and in mice receiving 2 Gy irradiation on day 2 (arrow). No significant differences were observed in initial tumour volume between treatment groups. Mean tumour volume did not exceed 1000 mm³ in mice treated with VNP pRA-TR and 2 Gy at 1 month. (B) Tumour doubling time and (C) growth delay, as determined from regression analysis of exponential tumour growth curves. Growth delay was determined from the calculated time to tumour volume of 1000 mm³, normalised against the PBS control. ^*P<0.05 compared with PBS. ^†P<0.05 compared with PBS and 2 Gy. (D) Kaplan–Meier survival curves after experimental treatments in mice receiving no irradiation, and in mice receiving 2 Gy irradiation on day 2 (arrow). Survival analysis was based on follow-up until death or killing. Significant differences in 30-day survival were observed between mice receiving VNP pRA-TR and PBS, and between mice receiving VNP pRA-TR and 2 Gy and PBS and 2 Gy (log-rank test, P<0.05).