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. 2009 Oct 20;101(10):1709–1716. doi: 10.1038/sj.bjc.6605375

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Copyright © 2009 Cancer Research UK

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Therapeutic efficacy of B7-H3 blockade in murine pancreatic cancer. The effect of B7-H3 blockade on pancreatic cancer was examined in vivo. PAN02 was orthotopically implanted in the pancreas of syngeneic C57BL/6 mice. B7-H3 blockade significantly inhibited tumour growth compared with controls. (P=0.036 and 0.0002 at 2 and 4 weeks, respectively).