Table 1.

Interactions and functions of specific domains in TSP-1 and TSP-2 in the regulation of angiogenesis^*

Domain	Binding Receptors or Molecules	Functions	References
NH2-Terminal	HSPGs	Adhesion of EC; co-receptor for LRP1	[Adams, 2001; Yang et al, 2001; Lawler, 2000] [Yang et al, 2001; Hahn-Dantona et al, 2001] [Chandrasekaran et al, 2000]
	LRP1	Clearance of MMPs 2 and 9
	α3β1	Stimulates angiogenesis; adhesion, spreading and chemotaxis of cells** Adhesion of HUMVEC to immobilized TSPs; chemotaxis of EC to soluble TSPs Stimulates angiogenesis	[Calzada et al, 2003]
	α6β1
	α9β1
	α4β1	Supports adhesion of venous EC and mediates chemotaxis of microvascular EC	[Staniszewska et al, 2007]
			[Calzada et al, 2004a]
Type I Repeats	Small latent TGFβ1 complex	Activation of latent TGFβ1**	[Schultz-Cherry et al, 1995; Ribeiro et al, 1999]
	CD36	Induces apoptosis in EC in vitro and in tumor-derived blood vessels in vivo	[Jimenez et al, 2000; Dawson et al, 1997]
Types I and II Repeats	pan-β1 integrins
Type III Repeats	αvβ3, αIIbβ3	Modulate EC adhesion, inhibit EC migration	[Calzada et al, 2004b; Short et al, 2005] [Adams, 2001; Lawler & Hynes, 1989]
		Adhesion of EC
COOH-Terminal	CD47/IAP	Antagonizes NO-mediated vasodilation	[Isenberg et al, 2006]
	αvβ3, αIIbβ3	Adhesion and spreading of EC and platelets	[Brown and Frazier, 2001]

HSPGs heparan sulfate proteoglycans; HUMVEC human umbilical vein endothelial cells; EC endothelial cells

^*Modified and reproduced, with permission, from Angiogenesis: An Integrative Approach from Science to Medicine, Paul Bornstein, Chapter 13. Edited by William D. Figg and Judah Folkman. Springer Science and Business Media, LLC, 2008

^**Function not shared with TSP2