Table I. Disease specific survival analysis of the NKG2D ligands MIC, RAET1E, RAET1G, ULBP1, ULBP2 and ULBP3.

Data presented for each ligand expression case. Combinations of ligand expression are only presented in cases where statistical significance was found.

Variable	Mean DSS (months)	Survival range (months)	Log-rank p-value	Cox regression p-value	HR	Lower CI	Upper CI
MICA expression
High	68	62-74	0.035	0.04	0.76	0.59	0.99
Low	56	47-65
ULBP1 expression
High	67	61-73	0.055	0.045	0.81	0.64	1.05
Low	58	50-66
ULBP2 expression
High	60	54-66	0.466	0.39	1.13
Low	67	60-74
ULBP3 expression
High	66	58-74	0.53	0.492	0.91
Low	63	57-70
RAET1E expression
High	65	58-72	0.642	0.299	0.84
Low	64	57-71
RAET1G expression
High	74	65-83	0.01	0.03	0.74	0.551	1
Low	62	56-67
MICA and ULBP1
Both high	67	60-73	0.018	0.006	0.83	0.7	0.97
Single high	66	57-74
Both low	50	38-62
MICA and RAET1E
Both high	68	62-74	0.02	0.014	0.86	0.77	0.97
Single high	61	51-72
Both low	44	30-59
MICA and RAET1G
Both high	77	68-87	0.003	0.005	0.84	0.74	0.95
Single high	64	56-71
Both low	54	44-64
ULBP1 and RAET1E
Both high	68	59-72	0.041	0.039	0.81
Single high	62	55-70
Both low	45	27-63
ULBP1 and RAET1G
Both high	73	63-84	0.027	0.032	0.83
Single high	65	58-72
Both low	57	48-65
RAET1E and RAET1G
Both high	76	67-86	0.004	0.002	0.84	0.77	0.99
Single low/ Both low	61	55-67