Table 1.
List of the genes up-regulated by enteric glial cells in intestinal epithelial cells.
| Gene Symbol | Genbank | Description | % up-regulation (/control) | Fold difference |
|---|---|---|---|---|
| TXNIP | NM_006472 | thioredoxin interacting protein | 217,60 | 3,18 |
| ANKRD1 | NM_014391 | ankyrin repeat domain 1 (cardiac muscle) | 169,22 | 2,69 |
| FN1 | U42593 | fibronectin 1 | 152,16 | 2,52 |
| TUBB3 | NM_006086 | tubulin, beta 3 | 149,94 | 2,50 |
| MGLL | AJ270950 | monoglyceride lipase | 135,97 | 2,36 |
| METTL7A | NM_014033 | methyltransferase like 7A | 132,96 | 2,33 |
| PKN2 | NM_006256 | protein kinase N2 | 128,33 | 2,28 |
| / | XM_166201 | synonyms: KIAA0056, MGC104671; Homo sapiens KIAA0056 protein (hCAP-D3), mRNA. | 115,09 | 2,15 |
| EPB41L2 | NM_001431 | erythrocyte membrane protein band 4.1-like 2 | 110,50 | 2,11 |
| AASS | AJ007714 | aminoadipate-semialdehyde synthase | 110,15 | 2,10 |
| ACTG2 | NM_001615 | actin, gamma 2, smooth muscle, enteric | 102,56 | 2,03 |
| B4GALT5 | NM_004776 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 102,38 | 2,02 |
| SNX2 | NM_003100 | sorting nexin 2 | 102,38 | 2,02 |
| VIP | NM_003381 | vasoactive intestinal peptide | 102,33 | 2,02 |
| EIF4A2 | NM_001967 | eukaryotic translation initiation factor 4A, isoform 2 | 102,14 | 2,02 |
| / | NM_019027 | RNA-binding protein | 101,66 | 2,02 |
| POLR3F | NM_006466 | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa | 94,46 | 1,94 |
| PNRC1 | NM_006813 | proline-rich nuclear receptor coactivator 1 | 93,24 | 1,93 |
| NPPB | NM_002521 | natriuretic peptide precursor B | 83,97 | 1,84 |
| / | BC017857 | Homo sapiens cDNA clone IMAGE:4690793, with apparent retained intron. | 82,20 | 1,82 |
| KRT8 | NM_002273 | keratin 8 | 81,96 | 1,82 |
| SAT1 | NM_002970 | spermidine/spermine N1-acetyltransferase 1 | 80,24 | 1,80 |
| ASS1 | NM_000050 | argininosuccinate synthetase 1 | 76,73 | 1,77 |
| S100A11P | NM_021039 | / | 75,22 | 1,75 |
| SLC7A7 | NM_003982 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 72,31 | 1,72 |
| HAGH | NM_005326 | hydroxyacylglutathione hydrolase | 69,54 | 1,70 |
| BNIP3L | AF536326 | BCL2/adenovirus E1B 19 kDa interacting protein 3-like | 69,19 | 1,69 |
| / | AF195968 | PRR5-ARHGAP8 fusion | 68,01 | 1,68 |
| BNIP3 | NM_004052 | BCL2/adenovirus E1B 19 kDa interacting protein 3 | 67,84 | 1,68 |
| IL18 | NM_001562 | interleukin 18 (interferon-gamma-inducing factor) | 67,14 | 1,67 |
| RDM1 | BC038301 | RAD52 motif 1 | 67,11 | 1,67 |
| FAM107B | NM_031453 | family with sequence similarity 107, member B | 65,70 | 1,66 |
| PLAC8 | NM_016619 | placenta-specific 8 | 63,77 | 1,64 |
| SMARCA1 | NM_139035 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 63,72 | 1,64 |
| PLOD2 | NM_000935 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 62,87 | 1,63 |
| TMSB4Y | NM_004202 | thymosin, beta 4, Y-linked | 62,77 | 1,63 |
| SCPEP1 | NM_021626 | serine carboxypeptidase 1 | 60,96 | 1,61 |
| LAMA5 | NM_005560 | laminin, alpha 5 | 60,53 | 1,61 |
| LAMC1 | NM_002293 | laminin, gamma 1 (formerly LAMB2) | 59,89 | 1,60 |
| METAP1 | BC030054 | methionyl aminopeptidase 1 | 59,55 | 1,60 |
| IQGAP2 | NM_006633 | IQ motif containing GTPase activating protein 2 | 58,98 | 1,59 |
| C1orf43 | NM_015449 | chromosome 1 open reading frame 43 | 56,86 | 1,57 |
| CASP4 | NM_001225 | caspase 4, apoptosis-related cysteine peptidase | 55,71 | 1,56 |
| BTG1 | NM_001731 | B-cell translocation gene 1, anti-proliferative | 54,63 | 1,55 |
| SLC2A1 | K03195 | solute carrier family 2 (facilitated glucose transporter), member 1 | 54,34 | 1,54 |
| DCTN2 | NM_006400 | dynactin 2 (p50) | 52,68 | 1,53 |
| TOP2A | NM_001067 | topoisomerase (DNA) II alpha 170 kDa | 52,42 | 1,52 |
| KRT18 | NM_000224 | keratin 18 | 51,16 | 1,51 |
| LAMC1 | M55210 | laminin, gamma 1 (formerly LAMB2) | 50,37 | 1,50 |
| PRC1 | BC005140 | protein regulator of cytokinesis 1 | 50,13 | 1,50 |
| IMPDH2 | NM_000884 | IMP (inosine monophosphate) dehydrogenase 2 | 49,46 | 1,49 |
| / | AF202922 | LRP16 protein | 48,20 | 1,48 |
| PLD3 | NM_012268 | phospholipase D family, member 3 | 46,99 | 1,47 |
| RNF4 | NM_002938 | ring finger protein 4 | 44,88 | 1,45 |
| / | AC060225 | Homo sapiens 3 BAC RP11-23J16 complete sequence. | 42,10 | 1,42 |
| SMARCA1 | NM_003069 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 41,18 | 1,41 |
| DYNLT3 | NM_006520 | dynein, light chain, Tctex-type 3 | 40,06 | 1,40 |
| PPARG | NM_015869 | peroxisome proliferative activated receptor, gamma | 38,92 | 1,39 |
| GLRX | AF069668 | glutaredoxin (thioltransferase) | 37,78 | 1,38 |
| PTK2 | NM_153831;NM_005607 | PTK2 protein tyrosine kinase 2 | 37,72 | 1,38 |
| CDH1 | NM_004360 | cadherin 1, type 1, E-cadherin (epithelial) | 36,87 | 1,37 |
| RNASE4 | NM_002937 | ribonuclease, RNase A family, 4 | 31,40 | 1,31 |
| CTSH | NM_004390 | cathepsin H | 29,45 | 1,29 |
| MKI67 | NM_002417 | antigen identified by monoclonal antibody Ki-67 | 29,28 | 1,29 |
| EIF2A | NM_032025 | eukaryotic translation initiation factor 2A, 65 kDa | 26,54 | 1,27 |
| TGFBI | BC000097 | transforming growth factor, beta-induced, 68 kDa | 25,95 | 1,26 |
| MLLT3 | NM_004529 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 22,42 | 1,22 |
| APOBEC3B | NM_004900 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 22,20 | 1,22 |
| ADD3 | NM_019903 | adducin 3 (gamma) | 20,82 | 1,21 |
| FTH1 | NM_002032 | ferritin, heavy polypeptide 1 | 15,97 | 1,16 |