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Hippocampal neurotoxicity of ADDLs occurs via a Fyn-dependent pathway. ADDL toxicity is completely blocked in slices from a Fyn knockout (KO) mouse. (Upper) Images of dead cells in the DG and CA3 area of (Left) Fyn wild-type or (Right) Fyn knockout mouse slice exposed to ADDLs for 24 hr. Cell death only occurs with Fyn wild-type genotype. (Lower) Quantitative comparison of cell death in Fyn wild-type and Fyn knockout slices. Error bars are means ± SEM for four to seven slices.
