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ADDLs block LTP. Incubation of rat hippocampal slices with ADDLs prevents LTP well before any overt signs of cell degeneration. Medial perforant path-granule cell LTP was readily induced in slices from young adult rats (•, see Materials and Methods). In contrast, hippocampal slices exposed to ADDLs for 45 min showed no lasting potentiation (▪), despite a continuing capacity for evoked action potentials.
