Table 3.
Positivity of antiphospholipid assays in patients with history of thrombosis
| Patient | Thrombosis | aPT-A | aPS/PT | aβ2GPI/CL | IgG aCL | IgM aCL | LAC |
|---|---|---|---|---|---|---|---|
| 1 | A | − | − | − | − | − | − |
| 2 | A | − | − | − | − | − | − |
| 3 | A | + | + | + | − | − | − |
| 4 | V | + | − | + | − | − | + |
| 5 | V | − | − | − | − | − | + |
| 6 | A,V | + | + | + | − | − | + |
| 7 | A | + | − | − | + | − | − |
| 8 | A | + | + | + | + | − | + |
| 9 | A | + | + | + | + | − | + |
| 10 | A | − | − | − | − | − | − |
| 11 | V | + | − | − | − | − | − |
| 12 | V | − | + | + | + | + | + |
| 13 | A,V | − | + | + | − | + | − |
| 14 | A | − | − | + | − | − | − |
| 15 | V | − | + | + | − | − | − |
| 16 | A,V | + | + | + | + | − | + |
A, with history of arterial thromboses; V, with history of venous thromboses; aPT-A, antiprothrombin antibody measured using high binding plates; aPS/PT, antiphosphatidylserine/prothrombin antibody; aβ2GPI/CL, β2-glycoprotein I-dependent anticardiolipin antibody; aCL, anticardiolipin antibody; LAC, lupus anticoagulant
Summary of thrombotic history: 1. Cerebral infarction (CI), occurring before diagnosis of systemic lupus erythematosus (SLE). No additional events with low-dose aspirin. 2. Left atrial thrombosis, found at the time of diagnosis of SLE. No recurrence with warfarin plus low-dose aspirin. 3. CI, occurring 21 years after diagnosis of SLE, while on low-dose aspirin. No further events after addition of warfarin. 4. Deep vein thrombosis (DVT) and pulmonary embolism (PE), occurring 3 years after diagnosis of SLE, while on low-dose aspirin. No further events after addition of warfarin. 5. PE found 2 years after diagnosis of SLE, while without any anticoagulation. Dipyridamole was added. Warfarin added 10 years after diagnosis of SLE to delay the progression of pulmonary hypertension. 6. Old lung infarction noticed 22 years after diagnosis of SLE, while under low-dose aspirin. No further episodes. 7. CI occurred 15 years before occurrence of SLE. 8. DVT occurred in the first year after diagnosis of SLE while under low-dose aspirin. Warfarin was added and no further episodes noticed. 9. PE, found 17 years after diagnosis of SLE while drug free. No episodes after addition of warfarin. 10. CI, occurring before diagnosis of SLE. 11. DVT, occurring 4 years after diagnosis of SLE. No recurrence after addition of warfarin. 12. DVT, found at the time of diagnosis of SLE. No recurrence after addition of warfarin and low-dose aspirin. 13. DVT, PE, both found at the time of diagnosis of SLE. No recurrence after addition of warfarin and low-dose aspirin. 14. Myocardial infarction occurring 24 years after diagnosis of SLE. CI found by further examination. No recurrence after low-dose aspirin and ticlopidine hydrochloride. 15. DVT, occurring 5 years after diagnosis of SLE while under no anticoagulation. No recurrence after addition of warfarin and low-dose aspirin. 16. CI, PE, both found at the time of diagnosis of SLE. No recurrence after addition of warfarin