Table 3.
Genotype Counts From Case-Control Studies Evaluating the Association Between the UCHL1 S18Y Variant and Parkinson's Disease Published Through July 1, 2008
| Country and Study (Reference No.) | Genotype | No. of Cases | No. of Controls | Recalculated Odds Ratioa | 95% Confidence Interval | P Value |
| Asia | ||||||
| China | ||||||
| Wang et al., 2002 (98) | SS | 40 | 45 | 1.00 | 0.802 | |
| SY | 82 | 80 | 1.15 | 0.66, 2.02 | ||
| YY | 38 | 35 | 1.22 | 0.62, 2.4 | ||
| Japan | ||||||
| Mizuta et al., 2006b (106) | SS | 149 | 199 | 1.00 | 0.165 | |
| SY | 340 | 366 | 1.22 | 0.94, 1.59 | ||
| YY | 124 | 171 | 1.00 | 0.72, 1.37 | ||
| Momose et al., 2002 (107) | SS | 71 | 61 | 1.00 | 0.136 | |
| SY | 119 | 122 | 0.84 | 0.54, 1.31 | ||
| YY | 40 | 65 | 0.53 | 0.30, 0.92 | ||
| Satoh and Kuroda, 2001 (23) | SS | 28 | 41 | 1.00 | 0.011 | |
| SY | 35 | 62 | 0.83 | 0.42, 1.64 | ||
| YY | 11 | 52 | 0.31 | 0.12, 0.74 | ||
| Zhang et al., 2000 (108) | SS | 52 | 35 | 1.00 | 0.095 | |
| SY | 77 | 86 | 0.60 | 0.34, 1.05 | ||
| YY | 31 | 39 | 0.54 | 0.27, 1.06 | ||
| Singapore | ||||||
| Tan et al., 2006 (109) | SS | 93 | 71 | 1.00 | 0.202 | |
| SY | 194 | 172 | 0.86 | 0.58, 1.27 | ||
| YY | 88 | 98 | 0.69 | 0.44, 1.07 | ||
| Australia | ||||||
| Australia | ||||||
| Mellick and Silburn, 2000 (100) | SS | 100 | 101 | 1.00 | 0.188 | |
| SY | 33 | 38 | 0.88 | 0.49, 1.56 | ||
| YY | 9 | 3 | 3.03 | 0.72, 17.81 | ||
| Europe | ||||||
| France | ||||||
| Elbaz et al., 2003 (97) | SS | 139 | 323 | 1.00 | 0.182 | |
| SY | 67 | 145 | 1.07 | 0.74, 1.55 | ||
| YY | 3 | 20 | 0.35 | 0.07, 1.21 | ||
| Levecque et al., 2001 (101) | SS | 76 | 64 | 1.00 | 0.852 | |
| SY | 33 | 24 | 1.16 | 0.59, 2.27 | ||
| YY | 5c | 5 | 0.84 | 0.19, 3.84 | ||
| Germany | ||||||
| Wintermeyer et al., 2000 (25) | SS | 169 | 128 | 1.00 | 0.059 | |
| SY | 51 | 65 | 0.59 | 0.38, 0.94 | ||
| YY | 9 | 7 | 0.97 | 0.31, 3.17 | ||
| Italy | ||||||
| Savettieri et al., 2001 (102) | SS | 118 | 115 | 1.00 | 0.999 | |
| SY | 46 | 45 | 1.00 | 0.60, 1.67 | ||
| YY | 5 | 5 | 0.97 | 0.22, 4.36 | ||
| Sweden | ||||||
| Carmine Belin et al., 2007d (99) | SS | 218 | 191 | 1.00 | 0.216 | |
| SY | 74 | 89 | 0.73 | 0.50, 1.07 | ||
| YY | 4 | 5 | 0.70 | 0.14, 3.31 | ||
| United Kingdom | ||||||
| Healy et al., 2006 (26) | SS | 1,074 | 1,028 | 1.00 | 0.54 | |
| SY | 409 | 418 | 0.94 | 0.79, 1.1 | ||
| YY | 44 | 36 | 1.17 | 0.73, 1.89 | ||
| North America | ||||||
| United States | ||||||
| Facheris et al., 2005 (92) | SS | 44 | 41 | 1.00 | 0.044 | |
| SY | 26 | 23 | 1.05 | 0.49, 2.26 | ||
| YY | 0 | 6 | 0 | 0, 0.62 | ||
| Hutter et al., 2008 (95) | SS | 1,191 | 1,324 | 1.00 | 0.388 | |
| SY | 509 | 621 | 0.91 | 0.79, 1.95 | ||
| YY | 57 | 71 | 0.89 | 0.61, 1.29 | ||
| Maraganore et al., 1999c (20) | SS | 95 | 64 | 1.00 | 0.068 | |
| SY | 35 | 42 | 0.56 | 0.31, 1.01 | ||
| YY | 2 | 4 | 0.34 | 0.03, 2.45 | ||
| Maraganore et al., 2004e (91) | SS | 120 | 48 | 1.00 | ||
| SY | 48 | 25 | 0.77 | 0.41, 1.45 | ||
| YY | 7 | 7 | 0.4 | 0.11, 1.42 | ||
| Zhang et al., 2000 (108) | SS | 108 | 105 | 1.00 | 0.285 | |
| SY | 40 | 36 | 1.08 | 0.62, 1.89 | ||
| YY | 5 | 1 | 4.86 | 0.53, 232.03 | ||
Abbreviation: UCHL1, ubiquitin carboxyl-terminal esterase L1 gene.
a
Unadjusted odds ratios were calculated by the authors of the present review using raw genotype data presented in published studies.
b
Excluding cases included in genotype counts in the Momose et al. study (107).
c
Incorrect count presented in the initial publication; corrected genotype count obtained from Maraganore et al. (91).
d
Incorrect counts presented in the initial publication; corrected genotype counts obtained courtesy of the author.
e
Excluding cases included in genotype counts in the Maraganore et al. study (20).