Table 2.
Crude and adjusted odds ratios of primary intracerebral haemorrhage for use of aspirin and other non-steroidal anti-inflammatory drugs estimated by multiple logistic regression
| Drug use | Cases (n=331) | Controls (n=331) | Crude odds ratio* | Adjusted odds ratio (95% CI)† | P value‡ |
|---|---|---|---|---|---|
| Aspirin in previous fortnight: | |||||
| No | 245 (74) | 264 (80) | 1.00 | 1.00 | |
| Yes | 55 (17) | 58 (18) | 0.93 | 1.00 (0.60 to 1.66) | 0.998 |
| Aspirin dose in previous fortnight: | |||||
| None | 245 (74) | 264 (80) | 1.00 | 1.00 | |
| Casual: used less than alternate daily | 19 (6) | 28 (8) | 0.66 | 0.65 (0.31 to 1.36) | 0.253 |
| ⩽1225 mg/week at least alternate daily | 16 (5) | 21 (6) | 0.84 | 0.86 (0.38 to 1.96) | 0.724 |
| >1225 mg/week at least alternate daily | 19 (6) | 9 (3) | 2.34 | 3.05 (1.02 to 9.14) | 0.047 |
| test for heterogeneity: χ2 (2 df) = 5.73, P=0.057 | |||||
| Non-steroidal anti-inflammatory drugs in previous fortnight: | |||||
| No | 258 (78) | 277 (84) | 1.00 | 1.00 | |
| Yes | 42 (13) | 47 (14) | 0.93 | 0.85 (0.45 to 1.61) | 0.611 |
| Aspirin in previous 3 days: | |||||
| None | 252 (76) | 284 (86) | 1.00 | 1.00 | |
| Low dose | 17 (5) | 21 (6) | 0.89 | 0.94 (0.42 to 2.07) | 0.871 |
| Moderate-high dose | 30 (9) | 20 (6) | 1.54 | 1.60 (0.76 to 3.37) | 0.215 |
| All aspirin doses | 50 (15) | 41 (12) | 1.30 | 1.42 (0.81 to 2.48) | 0.217 |
| Non-steroidal anti-inflammatory drugs in previous 3 days: | |||||
| No | 267 (81) | 288 (87) | 1.00 | 1.00 | |
| Yes | 31 (9) | 35 (11) | 1.00 | 1.03 (0.52 to 2.03) | 0.942 |
*
Univariate conditional logistic regressions not adjusting for confounding variables.
†
Adjusted odds ratio = odds ratio obtained from multivariate analyses adjusted for hypertension, serum cholesterol concentration, diabetes, previous cardiovascular disease, body mass index, exercise, alcohol intake, and smoking. ‡For adjusted odds ratios.